Supplemental material for Cables 1 protects p 63 from proteasomal degradation to ensure deletion of cells after genotoxic stress
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Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress
The p63 gene product regulates epithelial morphogenesis and female germline integrity. In this study, we show that cyclin-dependent kinase 5 and Abl enzyme substrate 1 (Cables1) interacts with the trans-activating (TA) p63alpha isoform to protect it from proteasomal degradation. Using the female germline of Cables1-null mice as an in vivo model, we demonstrate further that oocytes lacking Cable...
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تاریخ انتشار 2010